Current Clinical Research

DCR OB/GYN Project List


CAHILL

Cahill STATUS PURPOSE                                                              back to top
OMSS Phase 2    Pelvic Floor followup started 5/2018 The purpose of this research study is to continue to assess mothers enrolled in the primary trial to determine the impact of immediate versus dealyed pushing as well as other labor and delivery characteristics on medium-term maternal pelvic floor morbidity.
VAG PREP (Frolova) started 8/2015 The purpose of this research study is to determine effectiveness of vaginal cleaning before delivery for preventing infections.
BFF Breastfeeding Aim 3 (Lewkowitz) Started: 7/11/17;  stopped 10/9/17 -11/13/17 -airwatch The purpose of this research study is to evaluate how women like to receive health information and what effect it has on them.  To learn more about health disparities and how to improve them.
Exercise in Obese Pregnancy              (CADE)  REACT started: 11/2018 The purpose of this research study is to examine the effects of aerobic and resistance exercise on sugar metabolism and blood vessel function in pregnany women who are overweight and obese. This information may be important in reducing gestational diabetes and preeclampsia during pregnancy in overweight and obese women.
ICTS (Monks) Anesthesia pilot NOT STARTED The purpose of this pilot observational study is to explore the pharmacokinetics of Oxytocin at elective cesarean delivery.
L&D Cohort ongoing Ongoing data collection; retrospective chart review
PP NSAIDS Trial NOT STARTED Looking at effects of oxytocin levels after delivery.

MACONES

Macones STATUS PURPOSE                                                              back to top
MOD – 1000 cohort started 1/2017 The purpose of this research study is to determine if preterm birth is associated with disruptions in normal sleep and wake times during pregnancy. To also explore genetic reasons for sleep pattern disruptions.
MOD- eLAB started 4/2018 The purpose of this research study is to determine if the early life biological, environmental and psychosocial factors your baby experiences influence their social-emotional and brain development into early childhood.
Theme 2 EMMI pilot: term labor study started 2/2017 The purpose of this research study is to learn more about contraction patterns in the uterus during term labor.  Use of MRI and ECGI (EMMI-electromyometrial imaging) on abdomen to record contraction patterns.
Theme 2 EMMI pilot: preterm labor study started 8/2018 The purpose of this research study is to learn more about contraction patterns in the uterus during pre-term labor.  Use of MRI and ECGI (EMMI-electromyometrial imaging) on abdomen to record contraction patterns.
Theme 2 Non-pregnant cervical MRE                                  Yong Wang NOT STARTED The purpose of this research study is to evaluate cervical tissue through Magnetic Resonance Enterography (MRE).  The MRE uses magnetic waves to look at soft tissues, using MRI.
Theme 2 Placenta MRI PIIYong Wang  started 6/2018 The purpose of this research study is to develop a safe, noninvasive technology capable of assessing placental health in real time in early pregnancy.  The aim is to develop Placental Immune Imaging (PII), a system based on nonconventional magnetic resonance imaging (MRI) technique called diffusion basis spectrum imaging (DBSI).
Noninvasive EEG of fetal brain Yong Wang started 9/2018 The purpose of this research study is to measure fetal brain activity in the uterus during pregnancy.
U Chicago started 9/2018 The purpose of this research study is to identify a set of stress responsive epigenetic marks and gene expression traits in maternal stromal epithelial cells, fetal HLAG+cytotrophoblasts and in maternal and fetal immune cells at the maternal fetal interface.
PREVENAc at WU Started 2/2017 The purpose of this research study is to lower rates of surgical site infections after undergoing c-section in overweight and obese pregnant women by using a negative pressure wound therapy device to the incision immediately after surgery to help promote wound healing.
Lewkowitz:  Iron-Deficiency Anemia started 4/2018 The purpose of this research study is to determine safety and effectiveness of treating pregnant women with iron-deficiency anemia with an iron infusion versus the standard treatment of oral iron supplements.

WANG

WANG STATUS PURPOSE
Theme 2 Non-pregnant cervical MRE
NOT STARTED Mechanical Elastic property-Cervix remodeling; MRI w/amplifier on pelvic area; Evaluation of safety and comfort for pregnant women.

STOUT

STOUT STATUS PURPOSE                                                back to top
Viral Dynamics pre/post progesterone
formerly Vag Microbiome & PTB
started 6/2018 The purpose of this research study is to understand how underlying mechanisms can affect preterm birth.  If microbial changes in the vagina are associated with a risk of preterm birth.
Vaginal Microbiome Maternal Response and PTB- formerly Preterm Birth and Viruses-
**Name changed July 26, 2018 to match grant name**

started 10/2017 The purpose of this study is to analyze samples from the genome institute for viruses.  The hypothesis is that vaginal viral communities by themselves or thourhg their interaction with the vaginal microbiome and maternal host, are associated with preterm birth.
Elastography and PTB NOT STARTED The purpose of this research study is to estimate the predictive ability of quantitative cervical elastography for preterm birth in women presenting with symptoms of preterm labor.
Onset and duration of Hypertensive Disorders  in pregnancy (Josh Rosenbloom) NOT STARTED Market scan from 2006-2016 to evaluate the onset and duration of HTN disorders of pregnancy and long term cardio morbidity.
Hypertension and OB project (Beth Sabol and Heather Lopez) NOT STARTED The purpose of this research project is to determine the risk of adverse maternal & neonatal outcomes in women with stage 1HTN compared to normotensive women and those with stage 2 HTN.
and to estimate the incidence of pregnant women who would now meet criteria for stage 1 HTN and additional clinical interventions including serial growth US and antenatal testing based on the new AHA BP guidelines.
PPHTN  start 8/2015 The purpose of this research study is to determine the safety and benefits of postpartum Furosemide given with Potassium Chloride for preventing Severe Postpartum HTN in high risk women.
17OHP -C dosing

Started in COH7 7/2017

Started in COH3 11/2017

The purpose of this research study is to determine if a higher weekly dose of 500mg of 17OHP-C in obsese women results in higher amount of medication found in the blood compared to the standard dose of 250mg.
CHAP started 9/2015 The purpose of this research study is to evaluate the safety and benefits of treating mild chronic hypertension, or high blood pressure, during pregnancy.
Barriers to accessing treatment (Opiod Clinic Phone Study) started 3/2019 Determine access to opiate use disorder care for pregnant patients in the region.

CARTER

Carter STATUS PURPOSE                                                             back to top
Group Vs. Traditional  RCT PNC for DM started 9/2018 The purpose of this research study is to determine if group prenatal care versus traditional prenatal care will help improve blood sugar in pregnant women with either Type 2 or gestational diabetes.
Choosing Group PNC started 8/2018 All subjects in group prenatal care that do not meet criteria for Group Vs. Traditional care to assess which group will help improve blood sugar in pregnant women with either Type 2 or gestational diabetes.
Medicaid Teen. GPNC & repeat teen pregnancy started 9/2018 Analyzing medicaid and birth certificate data
Medicaid Adult. LARC Uptake in GPNC started 9/2018 Analyzing medicaid and birth certificate data
Project sugar                  CDP Cohort  started 3/2017 Analyzing Data pulled from IOB/EOB CDP w/ T1DM, T2DM or GDM.
ECP Trauma Aware Enhancement Evaluation started 4/2018 Trauma aware centering.  Enhancement to deal with stress (yoga), anxiety, PTSD, trauma during pregnancy (mental health provider in group setting).
Care Clinic (Dr. Kelly, Stout & Carter) CARE Clinic started: 4/2018 Data/buprenorphine tracking and collection for all women seen at CARE clinic.

RAGHURAMAN

Raghuraman STATUS PURPOSE                                                              back to top
Oxygen Effects Started 8/2018 The purpose of this research study is to see if giving mothers oxygen or room air for certain patterns of the baby’s heart monitoring can change the heart monitoring, neonatal outcomes or affect the baby’s routine cord blood results.

Bebbington-Fetal Care Center & Dicke-Ultrasound

BEBBINGTON / DICKE STATUS PURPOSE                                                              back to top
Fetal Care Registry   (Bebbington) started 11/2016 Data collection to gather information and evaluate outcomes of both mothers and infants seen in the fetal care center.
FLPC in TTTS (Bebbington) started 11/2016 Data collection to gather information and evaluate outcomes of both mothers and infants seen in the fetal care center and undergo surgery (using the Karl Storz Fetoscope) for twin-to-twin transfusion syndrome.
NAFTNET-Complicated Monochorinic TWIN Pregnancy Registry – (Warner/Bebbington) started 11/2016 Data collection on monochorionic twin pregnancy including their complications, outcomes and treatments.
Ultrasound Data – Outcomes for VP 6 – (Dicke) started 7/2017 Data collected on delivery and infant outcomes on all patients who completed an ultrasound at Barnes.  Review discrepencies between ultrasound findings and infant outcome with Dr. Dicke regularly and ongoing.  Data collected on follow up procedure outcomes on requested GYN ultrasounds.  Reports sent to Dr. Dicke for review regularly and ongoing.

HOEFGEN

HOEFGEN STATUS PURPOSE                                                              back to top
OTC registry NOT STARTED Clinical and Research Database for Fertility Preservation
OTC registry NOT STARTED Girls/women age 1 month-41 y.o. who opt to have cryopreservation and are willing to bank 20% of tissue collected for storage.
TTC NOT STARTED Boys/men at any age who opt to have cryopreservation and are willing to bank 20% of tissue collected for storage.

ENGLAND

ENGLAND STATUS PURPOSE                                                              back to top
Maxi K Channel started 2011   Investigation of control of muscle contractions of the uterus during labor by looking at channel proteins in uterine muscle.

KATHRYN LINDLEY- Cardiology

KATHRYN LINDLEY STATUS PURPOSE                                                              back to top
Cardiac Pregnancy Registry  started 8/2017 To better understand the causes, prognois, and treatment of pregnancy-associated heart conditions such as heart failure and preeclampsia.

Joel Garbow- Radiology (Nelson)

JOEL GARBOW STATUS PURPOSE                                                              back to top
IUGR – MRI-BOLD study             MRI and MRS in vivo started 11/2016 To evaluate placental function through MRI scanning to see if we can identify factors that ma ylead to adverse pregnancy outcomes including growth related outcomes such as a very small baby.  Determine, specifically, how oxygen in the blood affects lactate levels in the fetus and the placenta

Ellen Lockhart (Katie Dalton)

ELLEN LOCKHART STATUS PURPOSE                                                              back to top
Pilot study of autotitrated positive airway pressure (aPAP) compliance NOT STARTED APU/antepartum unit  enrollment area; enroll at 20 wks;  aPAP treat sleep apnea during pregnancy

WIHSC/JIT

WIHSC/JIT STATUS PURPOSE                                                              back to top
WIHSC started 2009 WIHSC collects and stores blood, fluid, tissue specimens and medical data from women, infants and their families who volunteer to participate in medical research.  This collection is shared with authorized researchers to study human diseases, tests and treatments in an effort to enhance efforts of prevention and detection.
Mysorekar started 2017 Samples used to study placenta infection in ZIKA virus subjects
Katherine Knoop (L&D) started 2018 Neonatal sepsis, a bloodstream infection caused by a variety of pathogens, accounts for 26% of all neonatal deaths and poses a greater risk for long-term cognitive developmental problems. I have developed a murine model of neonatal sepsis where sepsis pathogens initiate a cytokine storm by nonspecific activation of T cells. This study will evaluate if human T cells, isolated from cord blood, can also be nonspecifically activated by clinical isolates of neonatal sepsis. Additionally, this study would test for differences between term and preterm T cell responses to clinical isolates of sepsis.
Kristine Wiley (peds) started 2019 To develop a targeted multiplex assay for microbes of interest to characterize the vaginal microbiome in pregnant women.
Yehuda Ginosar (anesthesiology) started 2019 Examining the role of ESX1 repressor protein in the genesis of preeclampsia.
Mark Zaydman (pathology and immunology; genetics) NOT STARTED Evaluate the NAD metabolome in human breast milk and vaginal secretions. Correlate available NAD salvage substrates with the abundance of Lactobacilli species.

EISENBERG

EISENBERG STATUS PURPOSE                                                              back to top
LNG 20 (L102; Sponsor=M360) Enrollment complete; participants being followed The purpose of this study is to evaluate if an investigational Intrauterine System (IUS), called LNG20, is safe and effective birth control method.
LNG 20 (L105: Sponsor=M60) started 4/2019 The purpose of this study is to evaluate the FDA-approved IUS Liletta in treatment of women with heavy menstrual bleeding.

JUNGHEIM 

JUNGHEIM STATUS PURPOSE                                                              back to top
Granulosa Cell Study; (Brookheart) started 10/2016 Samples and data collected through WHISC.  The purpose is to determine wheter the ER stress pathway is ipacted in the general PCOS population by assessing expression levels of ER stress markers in PCOS and non-PCOS granulosa cells.
PCOS Knowledge Survey (Reschke) started 2/2018 Assessment of the awareness and knowledge of long term health risks associated with polycystic ovary syndrome(PCOS) among women with PCOS.
Sperm –  (Celia Santi) started 8/2017 De-identified semen samples given daily to identify new biomarkers and assess sperm fertility capacity.
Evaluation of the sperm membrane potential;  (Celia Santi) started 9/2018 Identifying and assessment of sperm fertility capacity in semen and saliva samples.
PPUL:  ACT or NOT  Yale (Industry) started 1/2017 Assessment of three management strategies used in pregnant women who have a PPUL to see which is most effective at resolving a PPUL without the women requiring any additional treatment afterwards.
Reproductive Medicine Collaborative Clinical Trials Program (Study Name TBD) NOT STARTED Nutritional supplements vs placebo during IVF cycle through pregnancy to look at outcomes of the pregnancy.

KOMMAGANI

KOMMAGANI STATUS PURPOSE                                                              back to top
Steroid Receptors in Endometrium;   Kommagani started 5/2017 Identify how pregnancy hormone, progesterone facilitates endometrial receptivity and decidualization.  How steroid receptors and accessory proteins mediate progesterone action in uterus.
Endometriosis study NOT STARTED Identify causes of endometriosis to assist in the development of a new tool to diagnose and treat endometriosis

MCNICHOLAS

MCNICHOLAS STATUS PURPOSE                                                              back to top
LIFE -Levonorgestrel Intrauterine System for Emergency contraception started 1/2012 Levonorgestrel Intrauterine System For Emergency contraception
EPIC/ OBS IU sub Observation study started 12/2011 Effectiveness of prolonged use of IUD/Implant for contraception
EPIC Progesterone OFS (Merck)* started 12/2016 Assessing Ovarian Function During Prolonged Implant Use
EPIC/ Removal/ IU sub completed enrollment
F/U 2 yrs – 8/1/19
determine what contraceptive methods women use after the removal of LARC; and estimate the unintended pregnancy rates of women using a variety of contraceptive methods after removal of LARC
EPIC RCT completed enrollment
F/U 3 yrs – 10/2020
Compare effectiveness of off-label use of implants vs effectiveness of on-label use in our patient population

MADDEN

MADDEN STATUS PURPOSE                                                              back to top
C3/ CMS Enrollment closed 2/2018-followup surveys only Evaluating contraceptive satisfaction, continuation and healthcare services received at C3. Using medical claims data to create a payment model for reimbursement to healthcare providers and insurance companies.
PCORI-funded implementation study    (UPFRONT) NOT STARTED Creating a shared decision making tool for providers and patients in regards to treatment of fibroids.
Family Planning patient registry Creating a database of C3 pts retrospectively and new pts prospectively
Teen Pregnancy Prevention program NOT STARTED Collaboration with Dr. Katie Plax, Kim Donica (grants)-Wash U The Spot to provide a teen pregnancy prevention program through videos at time of visits.
Right Time Initiative NOT STARTED The basic premise is to make a state wide impact in Missouri to increase access to high quality family planning services and access to contraception through community outreach.
Unprotected Sex Biomarkers Pilot NOT STARTED Feasibility Pilot Study looking for biomarker (PSA) for condom use during a 10 week patient participation plan.
Contraceptive Education-Phase II NOT STARTED Pilot study with Carley Zeal to test educational tool (Bedsider) about information on contraception.
Abortion-Consent Law NOT STARTED Retrospective chart review and prospective survey to address Pre/Post Abortion Law 11/2017.

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