Clinical Trials

Many of our physicians are also leading researchers in their specialties, making breakthroughs and contributing to discoveries that are shaping their fields. Their research may offer some of our patients the additional benefit of having access to treatments that are under review in clinical trials.

Enrolling in a study does not always include testing a new treatment. Participating in a study can be as simple as answering a phone survey every few months to help doctors better understand healthy development, the effectiveness of prevention behaviors or the progression of a disease state. You will never be enrolled in a clinical study without your consent, and our physicians will give you complete information about a study that interests you before you choose whether to take part.

Learn more on the Washington University Physicians website:
Read the frequently asked questions about clinical trials »

Get notifications from Volunteer for Health:
Register to hear when you may have matched to a study »

Find a study in the National Institutes of Health (NIH) registry:
Search studies in all specialties at Washington University »


Find a clinical trial in obstetrics and gynecology

To request more information about a study below, you may email dcr@wustl.edu.

Research: Obstetrics & Maternal-Fetal

  • Preterm birth

    PI: George Macones, MD • Sponsored by March of Dimes

    The Washington University March of Dimes Prematurity Research Center is recruiting 1,000 volunteers for a study that follows women throughout pregnancy. The purpose is to learn more about how the body changes during pregnancy and why some babies are born too early. Ultimately, we hope our research will help to lower the rate of preterm birth, which is higher in St. Louis (12.5% of live births) and St. Louis County (10.6%) than the national average (9.6%), especially among black women.

    Visit the Prematurity Research Center website to learn more »

  • 17OHP Dosing: Impact of a higher dose on the pharmacokinetics of 17-alpha hyroxyprogesterone caproate in obese women

    PI: Molly Stout, MD, MSCI

    The purpose of this research study is to determine if a higher weekly dose of 500mg of 17OHP in obese women results in a higher amount of the medication found in the blood compared to the standard dose of 250mg.

    Contact: Tracy Burger, RN, BSN
    314-747-1390 | tburger@wustl.edu

  • CHAP: Antihypertensive Therapy for Mild Chronic Hypertension during Pregnancy

    PI: Methodius Tuuli, MD • Sponsored by a NIH grant

    Antihypertensive therapy to a standardized BP goal <140/90, compared with ACOG recommendations (no treatment), for mild CHTN reduces the frequency of key adverse maternal and newborn outcomes associated with CHTN including 1) a composite perinatal outcome (perinatal death, placental abruption, severe preeclampsia or indicated PTB <35 weeks) and 2) SGA (birth weight <10th percentile).  The purpose of this study is to evaluate whether a BP treatment strategy to achieve targets that are beneficial for non-pregnant adults (<140/90 mmHg) is safe and effective during pregnancy. This is a multi-center randomized trial.

    Contact: Tracy Burger, RN, BSN
    314-747-1390 | tburger@wustl.edu

  • GDM group: Group versus Traditional Prenatal Care for Diabetes: A Randomized Controlled Trial

    PI: Ebony Carter, MD • Sponsored by CDTR funding

    A randomized trial to test group prenatal care on self-care activities, compared to traditional prenatal care, will improve glycemic control and, ultimately, maternal and neonatal outcomes in women with type 2 and gestational diabetes.

    Contact: Tracy Burger, RN, BSN
    314-747-1390 | tburger@wustl.edu

  • MAXI-K: The role and regulation of maxi-k channel during pregnancy

    PI: Sarah England, PhD • Sponsored by an NIH grant

    This is a prospective study looking at the control of muscle contractions of the uterus during labor by looking at channel proteins in the uterine muscle. These channel proteins are involved in muscle functions. Approximately 1000 women will be recruited from Barnes Jewish Hospital who are undergoing cesarean delivery or hysterectomy.

    Contact: Tracy Burger, RN, BSN
    314-747-1390 | tburger@wustl.edu

  • OMSS: Optimizing Management of the Second Stage of Labor

    PI: Alison Cahill, MD & Methodius Tuuli, MD • Sponsored by a NIH grant

    This is a multi-center randomized trial of nulliparous women to compare the effectiveness of immediate and delayed pushing in the second stage of labor. We aim to test the central hypothesis that immediate pushing in the second stage of labor increases spontaneous vaginal delivery, shortens duration of the second stage, and reduces adverse neonatal and maternal outcomes. Secondary aim is to determine the effect of immediate pushing on the rate of neonatal composite morbidity and determine the impact of immediate versus delayed pushing on objective and subjective measures of maternal pelvic floor morbidity.

    Contact: Tracy Burger, RN, BSN
    314-747-1390 | tburger@wustl.edu

  • OXYGEN Trial: Intrapartum maternal oxygen supplementation: Effects on the mother and neonate

    PI: Nandini Raghuraman, MD, MS

    The purpose of this research study is to see if giving mothers oxygen or room air for certain patterns in the baby’s heart monitoring can change the heart monitoring, neonatal outcomes, or affect the baby’s routine cord blood results. We are also studying if oxygen and room air affect the amount of stress we see in a mom and baby’s cells and tissues. Participants are randomized to receive either room air or oxygen supplementation.  A subset of randomized participants will undergo a neonatal MRI.

    Contact: Tracy Burger, RN, BSN
    314-747-1390 | tburger@wustl.edu

  • PANDA Trial: Preeclampsia and Nonsteroidal Drugs for Analgesia: a randomized non-inferiority trial

    PI: Jonathan Hirschberg, MD

    The purpose of this research study is to determine if the use of non-steroidal anti-inflammatories (NSAIDs), such as ibuprofen, worsen hypertensive diseases of pregnancy when given post-delivery. Participants are randomized at delivery to Standard Analgesia or NSAID-free analgesia pain management postpartum.

    Contact: Tracy Burger, RN, BSN
    314-747-1390 | tburger@wustl.edu

  • PII: Applying Diffusion Basis Spectrum Imaging to Characterize Human Placenta Immuno-response during normal term and preterm pregnancies

    PI: Nandini Raghuraman, MD, MS • PI: Yong Wang, PhD

    The purpose of this research study it to develop a safe, noninvasive technology capable of assessing placental health early in pregnancy. We aim to develop Placental Immune Imaging (PII), a system based on a nonconventional magnetic resonance imaging (MRI) technique. By doing this study, we hope to learn more about healthy, term pregnancies and identify characteristics of pregnancies at risk for preterm birth.

    Contact: Tracy Burger, RN, BSN
    314-747-1390 | tburger@wustl.edu

  • PREVENA: Prophylactic Negative Pressure Wound Therapy in Obese Women after Cesarean

    PI: Methodius Tuuli, MD • Sponsored by a NIH grant

    A randomized trial to determine the effectiveness of prophylactic Negative Pressure Wound Therapy (NPWT) in reducing the rate of surgical site infections (SSIs) after cesarean in obese women.  Assess the safety of prophylactic NPWT in obese women as measured by frequency of adverse events including skin blisters, erythema, wound bleeding, and prolonged wound drainage.  Determine the effect of prophylactic NPWT on the frequency and identity of bacteria, including antibiotic-resistant organisms, isolated from SSIs after cesarean in obese women.

    Contact: Tracy Burger, RN, BSN
    314-747-1390 | tburger@wustl.edu

  • Targeted lifestyle change (TLC) group prenatal care for obese women at high risk for gestational diabetes: A randomized controlled trial.

    PI: Ebony Carter, MD, MPH

    This study is a randomized controlled trial testing the intervention Targeted Lifestyle Change Prenatal Group Care (TLC).  The purpose of this study is to determine the effects of TLC on maternal and neonatal outcomes.  We enroll and randomize women, early in pregnancy, who are at high risk of developing gestational diabetes to receive either traditional prenatal care or TLC and follow them throughout pregnancy and postpartum.

    Contact: Tracy Burger, RN, BSN
    314-747-1390 | tburger@wustl.edu

  • Vaginal Prep: Vaginal Cleansing Before Cesarean Delivery to Reduce Infection: A Randomized Trial

    PI: Nandini Raghuraman, MD, MS

    A randomized trial to compare the standard-of-care preoperative abdominal cleansing to abdominal cleansing plus vaginal cleansing with povidone-iodine solution prior to cesarean delivery of women in labor.  To attempt to provide this Level 1 evidence by performing a clinical trial to test the central hypothesis that vaginal cleansing with povidone-iodine solution immediately prior to cesarean delivery reduces postcesarean infectious morbidity.

    Contact: Tracy Burger, RN, BSN
    314-747-1390 | tburger@wustl.edu

  • Women’s and infant’s health specimen collection and processing

    PI: Emily Jungheim, MD, MSCI

    The study aim is to create a structure to facilitate the collection of patient specimens for women and infant’s health research. The Women and Infants Health Specimen Consortium provides specimen collection, specimen storage and processing, as well as the maintenance of a comprehensive database of outcomes data.

    Contact: Tracy Burger, RN, BSN
    314-747-1390 | tburger@wustl.edu