Clinical Trials

Many of our physicians are also leading researchers in their specialties, making breakthroughs and contributing to discoveries that are shaping their fields. Their research may offer some of our patients the additional benefit of having access to treatments that are under review in clinical trials.

Enrolling in a study does not always include testing a new treatment. Participating in a study can be as simple as answering a phone survey every few months to help doctors better understand healthy development, the effectiveness of prevention behaviors or the progression of a disease state. You will never be enrolled in a clinical study without your consent, and our physicians will give you complete information about a study that interests you before you choose whether to take part.

Learn more on the Washington University Physicians website:
Read the frequently asked questions about clinical trials »

Get notifications from Volunteer for Health:
Register to hear when you may have matched to a study »

Find a study in the National Institutes of Health (NIH) registry:
Search studies in all specialties at Washington University »


Find a clinical trial in obstetrics and gynecology

To request more information about a study below, you may email dcr@wustl.edu.

Research: Reproductive Endocrinology & Infertility

  • Endometrial intervention to improve IVF success rates

    Emily Jungheim, MD

    The objective of this study is to find out if endometrial mechanical stimulation (i.e. endometrial biopsy) prior to embryo transfer increases clinical pregnancy and live birth rates. Previous studies have shown that mechanical endometrial stimulation prior to embryo transfer may have a positive effect on clinical pregnancy and live birth rates.
    Goal: 100 participants

    Inclusion criteria:

    • Women 18-40 years old
    • Normoovulatory women with regular menstrual cycles defined as a cycle duration of 21-35 days will be enrolled
    • Regular cycles

    Exclusion criteria:

    • Known endometriosis

    Contact: Kristina Cipolla, Research Coordinator
    314-286-2458 | cipollak@wudosis.wustl.edu

  • GEMINI (Genetics of Male Infertility Initiative)

    Kenan Omurtag, MD

    An NIH study established to identify the genetic causes of male infertility. One blood draw.
    Goal: 200 participants

    Inclusion criteria:

    • Men 18-55 years old
    • Men with extremely low sperm concentration (<5 million sperm/mL) on semen analysis

    Exclusion criteria:

    • Obstruction or absence of vas deferens
    • Varicocele
    • History of cryptorchidism
    • Radical pelvic surgery
    • Anejaculation
    • Spinal cord injury
    • Radiation treatments
    • Y chromosome microdeletions (YCMD) or karyotypic abnormalities

    Contact: Kristina Cipolla, Research Coordinator
    314-286-2458 | cipollak@wudosis.wustl.edu

  • Lifestyle and Ovarian Aging (LORE)

    Emily Jungheim, MD

    LORE is a research project working to determine the link between lifestyle factors and fertility. Participants are eligible for a $30 Target gift card. Must complete 3 surveys, a blood draw, and transvaginal ultrasound.

    Inclusion criteria:

    • Women ages 18-44
    • History of regular menstrual cycles
    • Not taking birth control pills

    Exclusion criteria:

    • Currently pregnant
    • History of ovarian surgery, infertility
    • Major chronic disease

    Contact: Kristina Cipolla, Research Coordinator
    314-286-2458 | cipollak@wudosis.wustl.edu

  • Reproductive Endocrinology / Fertility

    The Fertility and Reproductive Medicine Center participates in a number of individual and multi-center clinical studies. These studies use new interventions to diagnose and treat any number of conditions related to reproductive endocrinology and infertility, such as ovulation disorders, recurrent miscarriage and male factor infertility.

    Contact: Kristina Cipolla, Research Coordinator
    314-286-2458 | cipollak@wudosis.wustl.edu

  • The ACTorNOT Trial: Optimal treatment for women with a Persisting Pregnancy of Unknown Location (PPUL)

    Emily Jungheim, MD

    A randomized clinical trial of women at risk for an ectopic pregnancy: Active Treatment versus Expectant Management (no treatment). This is for stable women with a confirmed PPUL to be randomized to one of three strategies:

    1. Uterine evacuation followed by methotrexate (MTX) for some (those that have evidence of a non-visualized ectopic pregnancy)
    2. Empiric treatment with MTX for all
    3. Expectant management

    **Recruiting from our clinical population only

    Contact: Kristina Cipolla, Research Coordinator
    314-286-2458 | cipollak@wudosis.wustl.edu