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The Khabele lab recently published a new manuscript in BMC Cancer, titled “The Tie2 antagonist rebastinib reduces ovarian cancer growth in a syngeneic murine model.” Gupta VG, Roby KF, Pathak HB, Godwin AK, Gunewardena S, Khabele D. The Tie2 antagonist rebastinib reduces ovarian cancer growth in a syngeneic murine model. BMC Cancer. 2025 Feb 11;25(1):233. […]
On average in the US, 1 in 10 babies is born prematurely and, in many cases, the cause is unknown. However, there could be many contributing factors, nearly 40% of pregnant people who deliver before 37 weeks exhibit chronic placental inflammation, which happens when the mother’s immune system attacks the placenta. If we understood this […]
The Gomez-Lopez lab’s recently published article in The Journal of Immunology has been featured as a top read by the editor for the December 1st issue. Notably, only two articles are selected per issue for this recognition. Congratulations to the Gomez-Lopez lab!
PhD graduate student Kevin Prifti from the Frolova lab was recently awarded the CRepHS Biannual Best Paper Award, a friendly competition for first-author trainees within the Center. Kevin’s paper was also chosen as “Editor’s choice” by the journal in which he published, Biology of Reproduction. Congratulations, Kevin! Be sure to read the publication here: https://pubmed.ncbi.nlm.nih.gov/38857377/ – Citation: Prifti […]
Nardhy Gomez-Lopez, PhD presented at the WashU Medicine ODEI Faculty Showcase! This event was held in honor of Latiné/Hispanic Heritage Month. Our partners included the WashU Medicine Office of Diversity, Equity, and Inclusion(ODEI), the Department of Obstetrics & Gynecology, SOMOS WashU, the WashU COTAD Chapter, and the WashU LMSA Chapter. “From Passion to Purpose: My Journey, Inspirations, […]
Congrats to Dr. Sarah England who was inducted into the National Academy of Medicine this weekend!
Washington University in St. Louis’ Department of Obstetrics & Gynecology hosted our 2024 Dr. Jacob Probstein Visiting Professor Dr. Kristina Adams Waldorf, Professor of Obstetrics and Gynecology at the University of Washington. She presented her research entitled, “Unraveling Biology at the Maternal-Fetal Interface: Preterm Birth Studies in a Nonhuman Primate”.
The major goal of this proposal is to unveil non-infectious causes of preterm labor and birth and may lead to the development of a treatment – such as vitamin D, which is FDA-approved during pregnancy – to reduce the risk of preterm birth. “T Cells and IL-9 Signaling at the Maternal-Fetal Interface in Preterm Labor […]
Nardhy Gomez-Lopez, PhD, a professor of obstetrics & gynecology at Washington University School of Medicine in St. Louis, has received a four-year, $500,000 award from the Burroughs Wellcome Fund to further research into the immunobiology of the maternal-fetal interface and identify biomarkers to predict preterm labor and birth. One in 10 babies is born prematurely and, in many cases, […]
Debbie Frank joined the Department of Obstetrics and Gynecology as the Scientific Editor in 2012 and was promoted to Senior Scientific Editor in 2021. In this role, she helps faculty members, medical fellows, residents, post-doctoral fellows, and graduate students prepare research manuscripts, grant proposals, and fellowship applications. Debbie’s primary goal is to facilitate clear and […]
Viju Gupta, PhD and Audrey Johnston, MBA from the Center for Reproductive Health Sciences celebrated their graduation as two of only 30 WashU staff members in the inaugural cohort of the Emerging Leaders Program, sponsored by the Institute for Leadership Excellence. This is a 9-month, competitive program for WashU Staff members who manage individual contributors […]
The Annual Meeting of the American Association of Immunologists (Immunology 2024) was held in Chicago, Illinois! From our team, Dr. Nardhy Gomez-Lopez, Dustyn Levenson, and Valeria Garcia-Flores!
PhD student Kaci Martin from the Frolova lab received the Rosalind Kornfeld Student Leadership Award from the Academic Women’s Network last week. This award is given to a graduate or medical student that has demonstrated outstanding leadership in service to, or advancement of women within the community. Our Department Chair, Dr. Dineo Khabele, was there […]
Awards Galore! PhD student Kaci Martin from the Frolova lab received two awards from the Division of Biology and Biomedical Sciences last week – the Student Group Member of the Year Award and the Excellence in Research Award. If that wasn’t enough, Kaci’s PI, Assistant Professor Antonina Frolova, MD, PhD received the Outstanding Faculty Mentor. […]
The Center for Reproductive Health Sciences recently hosted its first Game Table Tournament! Thanks to the Wellness Champion Fund from HR, the CRepHS breakroom received a combination game table complete with ping pong, foosball, and air hockey. We then pitted lab-mates and faculty against one another in an epic event! Please congratulate our champions! – […]
The Center for Reproductive Health Sciences was well represented this week at the 29th Annual Graduate Research Symposium, hosted by the Washington University in St. Louis Graduate Student Senate on the Danforth Campus. From left to right: Postdoctoral Research Associates Juan Ferreira, PhD (Santi Lab) and Sara Pietroforte, PhD (Amargant i Riera Lab) participated as […]
MD/PhD student Dustyn Levenson in the Gomez-Lopez Lab was selected to present her work in a Block Symposium at “Immunology2024,” the annual meeting of the American Association of Immunologists (AAI), and will receive a 2024 AAI Trainee Abstract Award. We are incredibly proud of her hard work! Congratulations, Dustyn! #AAI2024
Yong Wang, PhD, Professor of Obstetrics and Gynecology, Electrical and System Engineering, Radiology, and Biomedical Engineering, in collaboration with Valerie Ratts, MD, Professor of Reproductive Endocrinology and Infertility, is making strides in discovery related to his project titled “Understanding Uterine Function and How it Relates to Reproductive Health.” This project was recently expanded to investigate […]
On the weekly Science Podcast, producer Kevin McLean talks with researcher Nardhy Gomez-Lopez, a professor in the department of obstetrics and gynecology and pathology and immunology in the Center for Reproductive Health Sciences at Washington University School of Medicine in St. Louis. The two discuss signaling between fetus and mother during childbirth and how understanding this crosstalk may one […]
An atlas revealing the activity of individual placental cells during childbirth offers insight on what happens at the maternal-fetal interface during term labor, according to a study supported by the National Institutes of Health (NIH). The atlas provides a single-cell analysis of the human placenta and its surrounding membranes and is the first to use […]
The Center for Reproductive Health Sciences (CRepHS) welcomed visiting speaker Alexa Sassin, MD, Assistant Professor, Department of Obstetrics and Gynecology, Baylor College of Medicine, on Jan. 5th as part of the CRepHS Seminar Series. Dr. Sassin’s impactful presentation on Polycystic Ovarian Syndrome (PCOS) research was well-received by seminar attendees over Zoom and in person at BJC-IH. […]
The Center for Reproductive Health Sciences (CRepHS) and the Center for Women’s Health Engineering (CWHE) hosted an open house event on December 5, 2023. At this collaborative event held on the Medical Campus, more than 70 attendees from the McKelvey School of Engineering and the School of Medicine were able to network and learn about reproductive health research, education […]
Dr. Nardhy Gomez-Lopez’s paper “Blockade of IL-6R prevents preterm birth and adverse neonatal outcomes” was published in eBioMedicine. Evidence before this study Prematurity remains as the leading cause of neonatal morbidity and mortality before five years of age globally. One in every three preterm infants is born to a pregnant individual with inflammation of the […]
Sarah England, PhD, Alan A. and Edith L. Wolff Professor of Medicine, Vice Chair of Research for the Department of Obstetrics and Gynecology, and Director of the Center for Reproductive Health Sciences at Washington University School of Medicine, recently received distinctive recognition of her exceptional research accomplishments and service in the field of obstetrics and […]
Reproductive biologist Sarah K. England, PhD, and two others from Washington University School of Medicine in St. Louis, have been elected to the National Academy of Medicine, a part of the National Academy of Sciences. Membership in the organization is one of the highest honors in the fields of health and medicine in the United […]
Peinan Zhao, PhD, Assistant Professor of Obstetrics and Gynecology, Washington University School of Medicine in St. Louis, received a new five year R01 grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) with co-principal investigator Molly Stout, MD, MS, Associate Professor of Obstetrics and Gynecology, University of Michigan. The R01 grant provides […]
Farners Amargant i Riera, PhD, was awarded an R00 for her project titled, “Mechanotransduction mechanisms of ovarian aging.” Dr. Amargant i Riera will examine how the increase in the biomechanical properties of the ovary with age are spatially and hormonally regulated and how they influence follicle transcriptome through the YAP1 pathway. Overall, the proposed studies […]
Happy National Postdoc Appreciation Week! WashU has a diverse community of over 850 postdocs from different parts of the world. Their commitment to research, teaching, and mentorship not only enhances the academic community at Washington University, but also plays a pivotal role in advancing science, technology, and scholarship across the country and around the world. We […]
Antonina Frolova, MD, PhD, Assistant Professor of Obstetrics and Gynecology, was awarded an R21 for her project titled, “Metabolic mechanisms of uterine contractility in labor.” The objective of the project is to determine the mechanisms driving obesity-related labor dysfunction. This research may lead to new options for pharmacologic and behavioral interventions to optimize myometrial energy […]
Jeannie Kelly, MD, MS, Associate Professor of Obstetrics and Gynecology, and Yong Wang, PhD, Professor of Obstetrics and Gynecology, were awarded an R01 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). The project is titled, “The Opioid in Pregnancy: Imaging of Oxygenation, Inflammation, and Development in Brain & Placenta […]
Dr. Maggie Mullen has been awarded grant funding through the 2023 Victoria’s Secret Global Fund for Women’s Cancers Career Development Award, in partnership with Pelotonia & AACR, Targeting platinum chemotherapy resistance in ovarian cancer. **This two-year grant starts in September.** These accomplishments are impossible without our amazing research and clinical teams and the sponsorship of our […]
Sumegha Mitra, PhD, Associate Professor of Obstetrics and Gynecology, received a 3-year, $754,414 Research Scholar Grant, RSG-22-070-01-TBE, from the American Cancer Society (ACS) to study high-grade serous ovarian cancer (HGSOC). Dr. Mitra’s ACS-funded project is titled “Protein Homeostasis Network Regulates Oncogenic Signaling in High-Grade Serous Ovarian Cancer.” “My American Cancer Society grant will study how adaptive […]
Eric P. Newman Education Center @ Washington University Medical CenterOctober 19, 2023 8:00 AM – October 20, 2023 3:30 PM Coordinator Michelle R Padgett, MS, ATC, Washington University CME Agenda This conference is offered as an in-person course only. Thursday, October 19, 2023 7:30am Registration & Continental Breakfast 8:10 Welcome – Makeba Williams, MD, NCMP Session I […]
The lab of Celia Santi, MD, PhD, has been busy this summer with scientific discussions and networking opportunities! Dr. Santi presented her lab’s work on non-hormonal contraception during the “Male Contraceptive” session at the Society for the Study of Reproduction (SSR) 56th Annual Meeting. The “Reproductive Sciences: From Innovation to Impact” SSR meeting took place in Ottawa, Canada, […]
Amanda Compadre, MD, and Lily van Biljon recently published an article in Clinical Cancer Research titled “RAD51 Foci as a Biomarker Predictive of Platinum Chemotherapy Response in Ovarian Cancer.” This paper demonstrates that RAD51 foci are a robust marker of platinum chemotherapy response and survival in ovarian cancer. This research was led by Mary (Maggie) Mullen, MD. […]
Antonina (Toni) Frolova, MD, PhD, a maternal-fetal medicine physician and Assistant Professor of Obstetrics and Gynecology, applied and was selected to be a scholar in the Doris Duke COVID-19 Fund to Retain Clinical Scientists (CFRCS) program at Washington University School of Medicine. As an early career physician-scientist, the program will benefit Dr. Frolova’s navigation of this stage […]
Magdalena Nelson, MBA, Director of Research and Business Administration in the Department of Obstetrics and Gynecology, is this year’s recipient of the WashU School of Medicine Research Support Award. This award from the medical school recognizes employees for exceptional performance or cooperation, outstanding leadership, and superior quality of service. As a distinguished honors awardee, Magdalena was […]
The WashU Gynecologic Oncology Tissue Bank celebrated collecting its 100th tissue sample for bench-to-bedside research endeavors. Along with this notable achievement in specimen collection, the labs of Drs. Dineo Khabele and Maggie Mullen have instituted a newly organized process for collecting and managing samples, and are developing research on patient-derived organoids. “We couldn’t have done it without the hard […]
The Center for Reproductive Health Sciences celebrated its graduates! Congrats to all and good luck with your future endeavors!
The Mullen lab at the Siteman Cancer Center’s Center for Genome Integrity retreat. Viju Gupta, PhD from the Khabele lab also presented! Dr. Amanda Compadre received an honorable mention for the best Oral Presentation and Olivia Graham and Jeimmy Rodriguez of our Tissue Bank got an honorable mention for the best poster presentation. Big wins […]
The WashU Gynecologic Oncology Tissue Bank just celebrated collecting its 100th tissue sample for bench-to-bedside research endeavors. Along with this notable achievement in specimen collection, the labs of Drs. Dineo Khabele and Maggie Mullen with the Center for Reproductive Health Sciences (CRepHS) and the Division of Gynecologic Oncology (GynOnc) have instituted a newly organized process for collecting and managing […]
Members of CRepHS recently voyaged to Brisbane, Australia to present at and attend the 70th Annual Meeting of the Society for Reproductive Investigation (SRI). Sicheng Wang and Yiqi Lin (Wang Lab) both won the SRI President’s Presenter’s Award, Patricia Strutz, MD, MSCI (England Lab) and Zhexian Sun (Wang Lab) both won the Poster Award, and […]
“The study team, led by Yong Wang, Ph.D., and Alan Schwartz, M.D., Ph.D., at Washington University in St. Louis, and Alison Cahill, M.D., at the University of Texas at Austin, initially developed EMMI using a sheep model and reported their findings in Science Translational Medicine. In the new study, the team tailored EMMI for human clinical use […]
Juan Ferreira, PhD, postdoctoral research associate in the Santi Lab, recently earned a fellowship award from the Lalor Foundation for his research on a new assay to evaluate sperm fertilization capacity in infertile patients. “I would like to express thanks to Drs. England, Blanco, Lishko and Frank for their support of this project,” Ferreira states, “and […]
WashU’s Deptartment of OBGYN has once again achieved a US TOP 10 RANKING! Funds awarded to our department by the National Institutes of Health totaled $6.4M in 2022, as reported by Blue Ridge Institute for Medical Research #BRIMR. Congrats to our amazing & dedicated research teams!
The members of CRepHS held a Valentine’s Bake-Off and card-making party. Photos courtesy of Julie Emmerich!
To fertilize an egg, human sperm must undergo a process in which the membrane becomes more negative inside. The ion channel responsible for this membrane hyperpolarization has long been unclear. In this publication, the Santi and Denton labs describe a screen to identify inhibitors of a strong candidate – the sperm-specific potassium channel SLO3. They […]
Celia Santi, MD, Ph.D., recently received a two-year grant from the Bill & Melinda Gates Foundation. The $435,000 award, beginning November 2022, will support her lab’s efforts in screening and characterizing a new class of female-controlled non-hormonal contraceptive agents using in vitro and in vivo assays. Dr. Santi’s research project is titled, “SLO3 inhibitors: a […]
Two new trainees recently began their fellowships through the Department of Ob/Gyn’s T32 training grant titled, “Clinical Outcomes Research Training in Female Lower Urinary Tract Disorders,” led by Co-Principal Investigators Jerry Lowder, MD, MSc, and Siobhan Sutcliffe, PhD, and funded through the NIH NIDDK. Dr. Victoria Leigh Brown received her PhD in Anthropology from Binghamton […]
The Center for Reproductive Health Sciences (CRepHS) is pleased to share our newsletter, released February 2022. The CRepHS Newsletter will be distributed on a quarterly basis.